Pathways
Biotin Metabolism
Description:
Biotin is a water-soluble Vitamin required by all organisms by virtue of its essential role in carboxylation reactions. Whereas animals lack the ability to synthesize Biotin, it is synthesized by microorganisms and plants and therefore is widespread in the food supply at low concentrations relative to most water-soluble Vitamins (Ref.1). The highest level of Biotin occurs in organ meats such as liver and kidney, but it is low in meats, most vegetables, and fruits. It is also known as Vitamin-H. This member of Vitamin B-Comp...
References:
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B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review.
Nutrients. 2016 Jan 27;8(2):68. doi: 10.3390/nu8020068. Review. -
Molecular genetics of biotin metabolism: old vitamin, new science.
J. Nutr. Biochem. 2005 Jul;16(7):428-31. -
Structural enzymology of biotin biosynthesis.
FEBS. Lett. 2001 Apr 20;495(1-2):7-11. -
Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies.
Appl Environ Microbiol. 2017 Dec 15;84(1). pii: e02084-17. doi: 10.1128/AEM.02084-17. Print 2018 Jan 1.
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